Publications by authors named "T Guillard"
Background: The incidence of infective endocarditis is increasing over time. Data on the impact of minimum inhibitory concentration (MIC) of amoxicillin on treatment outcomes are scarce. The objective of this study was to describe the epidemiology of infective endocarditis and to evaluate whether the MIC of amoxicillin might influence mortality.
View Article and Find Full Text PDFThe antibacterial oxidative response, which relies on the production of hydrogen peroxide (H2O2) and hypothiocyanite (OSCN-), is a major line of defense protecting the human airway epithelium (HAE) from lesions when infected. The in vitro studies of the oxidative responses are performed mainly by one-shot H2O2 exposure that does not recapitulate the complex H2O2/LPO/SCN- system releasing the reactive oxygen species in airway secretions. A cell-free in vitro assay mimicking this system has been described but was not fully characterized.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the link between blood eosinophil count (BEC) and airway microbiota in stable COPD patients.
- It involved 59 adult patients, categorized into low BEC (<300/mm) and high BEC (≥300/mm) groups, assessing clinical features and microbiota.
- Results showed that patients with high BEC experienced more frequent exacerbations and worse symptoms, but microbiota composition was similar across both groups.