Publications by authors named "T Gruenewald"
Objective: Emerging work suggests that affect regulation strategies (e.g., active coping, anger expression) predict disease and mortality risk, with sometimes divergent estimates by sex or education levels.
View Article and Find Full Text PDFIntroduction: We address the extent to which adolescent cognition predicts dementia risk in later life, mediated by educational attainment and occupational complexity.
Methods: Using data from Project Talent Aging Study (PTAS), we fitted two structural equation models to test whether adolescent cognition predicts cognitive impairment (CI) and Ascertain Dementia 8 (AD8) status simultaneously (N = 2477) and AD8 alone (N = 6491) 60 years later, mediated by education and occupational complexity. Co-twin control analysis examined 82 discordant pairs for CI/AD8.
Article Synopsis
- The study investigated how genetic variations in cytokines from different T helper subsets affect susceptibility to SARS-CoV-2 by analyzing samples from 58 individuals living with infected persons.
- It categorized households into three groups: all members infected, mixed infection status, and entirely negative, identifying significant differences in the cytokines TGF-β1 and IL-6 across these groups.
- The research suggests that the balance of these cytokines could influence transmission and susceptibility to SARS-CoV-2, with higher TGF-β1 expression linked to infection and a polymorphism associated with higher IL-6 levels correlating with reduced susceptibility.
During the coronavirus pandemic, evidence is growing that the severity, susceptibility and host immune response to SARS-CoV-2 infection can be highly variable. Several influencing factors have been discussed. Here, we investigated the humoral immune response against SARS-CoV-2 spike, S1, S2, the RBD, nucleocapsid moieties and S1 of seasonal coronaviruses: hCoV-229E, hCoV-HKU1, hCoV-NL63 and hCoV-OC43, as well as MERS-CoV and SARS-CoV, in a cohort of 512 individuals.
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