Immunotherapy and gene therapy in prostate cancer treatment.

There are few methods bringing several relatively recent advances in therapy of certain types of prostate cancer. Belonging to personalized therapies, they use cells (normal or pathologic) from the patient, modify and reintroduce them in the patient's body, leading to an increased efficiency against the neoplastic tissue, proving to increase the patient's lifespan and/ or tumor progression.

Prostate cancer between prognosis and adequate/proper therapy.

Knowing the indolent, non-invasive nature of most types of prostate cancer, as well as the simple fact that the disease seems more likely to be associated with age rather than with other factors (50% of men at the age of 50 and 80% at the age of 80 have it [], with or without presenting any symptom), the big challenge of this clinical entity was to determine severity indicators (so far insufficient) to guide the physician towards an adequate attitude in the clinical setting. The risk of over-diagnosing and over-treating many prostate cancer cases (indicated by all the major European and American studies) is real and poses many question marks. The present paper was meant to deliver new research data and to reset the clinical approach in prostate cancer cases.

[Late results in 170 patients operated on for breast cancer].

The authors investigated the late results, or survival at 5 years after the intervention, in 170 patients operated for breast cancer. The total number of survivors at 5 years was of 71 patients, of which 78 belonged to stages I and II, and only 3 to stage III. The authors present their personal attitude for such cases, and stress some of the difficulties encountered in the application of complex therapy.

[Difficulties in diagnosis and surgical treatment of subacute and chronic thyroiditis].

Out of a total number of 875 cases of thyroid affections of various origins, hospitalized in the two surgical clinics of Tîrgu-Mureş, the authors selected 16 cases of subacute and chronic thyroiditis. They indicate the difficulties encountered in establishing the diagnosis before surgery, a fact that determined wide excisions in extremely difficult local conditions. They suggest, as a first therapeutic attitude, a conservative treatment with steroid drugs, antibiotics and roentgentherapy (when necessary), and, if such treatments fail, or when malignancies are suspected, as well as compression phenomena have developed, surgical treatment preceded by an extemporaneous anatomo-pathological examination.