Publications by authors named "T Greulich"
This report describes family members with alpha-1 antitrypsin (AAT) deficiency arising from two rare alleles of - p.(Phe76del) and p.(Asp280Val) along with the more common deficiency allele, Pi*Z.
View Article and Find Full Text PDFBackground: Currently, there is conflicting information and guidance on the effective management of Alpha 1 Antitrypsin Deficiency (AATD). Establishing a consensus of assessment and disease management specific to AATD is important for achieving a standardized treatment pathway and for improving patient outcomes. Here, we aim to utilize the Delphi method to establish a European consensus for the assessment and management of patients with severe AATD.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the differences in chronic obstructive pulmonary disease (COPD) between genders in patients with alpha-1 antitrypsin deficiency (AATD) using data from the EARCO registry.
- It analyzed 1283 AATD patients and found that while women reported less smoking and alcohol consumption, they had a higher prevalence of bronchiectasis despite better lung function.
- Results indicated that women experienced a similar symptom burden as men but had higher rates of exacerbations, suggesting that treatment approaches may need to be adjusted for female patients.
Article Synopsis
- Chronic obstructive pulmonary disease (COPD) patients are at high risk for acute exacerbations and community-acquired pneumonia, highlighting the need for accurate differentiation between these conditions due to their differing treatments and outcomes.
- This study evaluated selected gene transcripts from peripheral blood mononuclear cells (PBMCs) to distinguish between patients with acute exacerbations of COPD, those with CAP and COPD, and CAP without prior COPD.
- The results indicated that specific gene expressions (YWHAG and others) effectively predicted disease conditions with up to 100% accuracy, significantly outperforming traditional clinical markers in differentiating AECOPD from CAP.