Publications by authors named "T Grandmougin"
Assessment programs recently designed to follow-up patients with Huntington's disease (HD) in therapeutic trials have not included electrophysiological testing in the list of mandatory examinations. This omission is likely due to the current lack of data establishing a clear correlation between the electrophysiological results and those of clinical assessment. We address this issue in a cohort of 36 patients at relatively early stages of the disease (I and II).
View Article and Find Full Text PDFArticle Synopsis
- Huntington's disease is a genetic neurodegenerative condition that affects motor and cognitive functions, currently without a cure; this study investigated the effects of fetal striatal neuroblast transplantation in patients.
- Five patients with mild to moderate Huntington’s disease underwent grafts with human fetal neuroblasts in both striata, with assessments after one year revealing increased metabolic activity in some patients compared to untreated controls.
- Three out of the five patients showed functional improvements in motor and cognitive abilities, indicating that fetal neural grafts may provide a potential therapeutic approach for managing Huntington's disease symptoms.
This study describes issues related to the safety and tolerability of fetal striatal neural allografts as assessed in five patients with Huntington's disease. Huntington's disease (HD) is characterized by motor, cognitive, and behavioral disturbances. The latter include psychological disturbances and, as a consequence, we took particular care to analyze behavioral changes, in addition to the usual "safety" follow-up.
View Article and Find Full Text PDF