Publications by authors named "T Granato"
Information about impacts of long-term biosolids application on soil microbial populations and functional groups and N cycling is important for evaluating soil health and agroecosystem sustainability under long-term biosolids application. Mine spoil plots received annual biosolids application from 1973 to 2010 at low (16.8 Mg ha yr), medium (33.
View Article and Find Full Text PDFCutaneous melanoma is a highly aggressive skin cancer. It is estimated that 5% to 10% of the underlying mutations are hereditary and responsible for familial (or hereditary) melanoma. These patients are prone to the early development and higher risk of multiple melanomas.
View Article and Find Full Text PDFArticle Synopsis
- Ovarian cancer (OC) is often diagnosed late with a poor prognosis, inspiring significant research into biomarkers for early detection.* -
- Human epididymis protein 4 (HE4) is a crucial serum test for diagnosing OC and is also linked to the cancer's prognosis and recurrence.* -
- This review aims to explore HE4's role in OC processes such as proliferation, angiogenesis, and immune response, which could enhance its utility in diagnosis, prognosis, and targeted therapy.*
Background: Hereditary ovarian cancers (HOC) represent about 23% of ovarian cancer (OC) cases: they are most frequently related to germline mutations in the BRCA genes.
Objective: We aimed to compare CA125/HE4 serum levels and Computed Tomography (CT) features at time of ovarian cancer (OC) diagnosis in two populations: BRCA mutant and BRCA wild-type (WT) OC, and to investigate the relationship between this laboratory and radiological biomarker and BRCA mutation status.
Methods: This retrospective study included 60 newly diagnosed OC patients with FIGO stage IIIC-IV disease, tested for BRCA1/2 germline mutation status of which preoperative CT scan and serum tumor marker assay were available.