Publications by authors named "T Govind Pai"

Rationale: Chylothorax is a rare adverse effect that is associated with dasatinib, a tyrosine kinase inhibitor administered for chronic myeloid leukemia (CML) treatment. Most reported cases have described standard dosing. In this case report, we described a 43-year-old male patient with CML who developed chylothorax after 4 years of low-dose dasatinib therapy.

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Tobacco smoking is prevalent across the world and causes numerous diseases. Cigarette smoke (CS) compromises immunity, yet little is known of the components of CS that impact T cell function. MR1 is a ubiquitous molecule that presents bacterial metabolites to MAIT cells, which are highly abundant in the lungs.

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Less than 20 cases of primary hepatic rhabdomyosarcoma have been reported in literature. The authors present this occurrence in a neonate with paravertebral and peritoneal disease. Histopathology was the solution to authors' diagnostic dilemma.

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Article Synopsis
  • - During pregnancy and lactation, mammals experience significant changes in their intestinal epithelium, leading to an increase in intestinal surface area through the expansion of villi.
  • - The RANK-RANKL molecular pathway is crucial for this process, protecting gut cells from death and promoting intestinal stem cell activity, which results in villous elongation.
  • - Mice lacking RANK in their intestinal epithelium have offspring that are heavier and more prone to glucose intolerance, highlighting the importance of RANK-RANKL in both immediate and long-term health outcomes for offspring.
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Article Synopsis
  • ALC-positive lung cancers generally respond well to oral tyrosine kinase inhibitors, with Lorlatinib being a preferred option after previous treatments; this study examines its use in patients who progressed or couldn't tolerate earlier therapies.
  • In a study of 38 patients treated with Lorlatinib, most had extensive metastatic disease (mainly to the brain and bones), with a median follow-up of 49 months, revealing that 84% experienced disease control.
  • Results indicated a median progression-free survival of 16 months and overall survival of 22 months, with common side effects including elevated cholesterol and triglycerides; some patients needed dose adjustments due to these toxicities.
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