Publications by authors named "T Gotwald"
Objective: To assess the prognostic value of MOG antibodies (abs) in the differential diagnosis of acquired demyelinating syndromes (ADS).
Methods: Clinical course, MRI, MOG-abs, AQP4-abs, and CSF cells and oligoclonal bands (OCB) in children with ADS and 24 months of follow-up were reviewed in this observational prospective multicenter hospital-based study.
Results: Two hundred ten children with ADS were included and diagnosed with acute disseminated encephalomyelitis (ADEM) (n = 60), neuromyelitis optica spectrum disorder (NMOSD) (n = 12), clinically isolated syndrome (CIS) (n = 101), and multiple sclerosis (MS) (n = 37) after the first episode.
Background: Myelin oligodendrocyte glycoprotein (MOG) antibodies have been recently described in children with acute disseminating encephalomyelitis (ADEM), but the clinical and neuroradiological characterisation of this subgroup is lacking.
Objective: To compare the clinical and neuroradiological features of paediatric ADEM with and without MOG antibodies.
Methods: Clinical course, cerebrospinal fluid (CSF)-, MRI studies, outcome and MOG status of 33 paediatric ADEM prospectively studied were reviewed.
Article Synopsis
- The study tested sunitinib, a drug targeting multiple pathways, in patients with recurring glioblastoma to assess its effectiveness and safety.
- No objective tumor responses were observed, with a low 6-month progression-free survival (PFS) rate of 12.5%, and median overall survival (OS) was 9.2 months.
- Despite minimal effectiveness, some patients with high c-KIT expression showed improved PFS, indicating a potential subgroup that might benefit from the treatment.
Background: Onchocerciasis has been implicated in the pathogenesis of epilepsy. The debate on a potential causal relationship between Onchocerca volvulus and epilepsy has taken a new direction in the light of the most recent epidemic of nodding syndrome.
Objective: To document MRI changes in people with different types of epilepsy and investigate whether there is an association with O.
Background: Acute cerebellitis (AC) is characterized by cerebellar symptoms and magnetic resonance imaging (MRI) changes primarily confined to the cerebellum.
Objective: To analyze the neurological and cognitive long-term outcome of children with AC.
Methods: Children with AC diagnosed by typical clinical features and MRI findings were included in this retrospective study.