Acute, Subchronic, and Genetic Toxicity Assessments of a Composition of Fruit Rind and Seed Extracts.

LN19183 is a standardized composition of (Christm) Swingle (CA) fruit rind and L. (TC) seed extracts that have recently been demonstrated to increase resting energy expenditure (REE) and reduce body fat in rats. CA and TC are important herbs in traditional medicine for various health benefits.

A Synergistic Botanical Composition Increases Resting Energy Expenditure and Reduces Adiposity in High-Fat Diet-Fed Rats.

Objective: An imbalance between dietary energy intake and energy expenditure may result in body fat gain or obesity. Increasing resting energy expenditure (REE) is an attractive strategy for managing body fat gain. The objective of the current study was to generate proof-of-concept data on a synergistic composition (LN19183) of fruit rind (CA) and seed (TC) extracts to increase REE and reduce body fat gain in a high-fat diet (HFD)-fed rats.

A synergistic blend of fruit rind and leaf extracts enhances myogenic differentiation and mitochondrial biogenesis and muscle growth and strength in mice.

Background: A proprietary combination of fruit rind and leaf extracts (LI80020F4, CinDura) improved the physical performance and muscle strength of resistance-trained adult males.

Objective: This study assessed the underlying mechanisms of the ergogenic potential of LI80020F4 in and models.

Methods: The individual extracts and their combination (LI80020F4) were assessed for nitrite production in EAhy926 human endothelial cells.

Toxicological Assessments of a Proprietary Blend of Fruit Rind and Seed Extracts: Acute, Subchronic, and Genetic Toxicity Studies.

LN18178 (Tesnor) is a standardized, proprietary composition of aqueous ethanol extracts of fruit rind and seeds. The present study demonstrates a broad-spectrum toxicological evaluation of LN18178 utilizing and preclinical models following the Organization for Economic Cooperation and Development (OECD) guidelines for testing chemicals. Wistar rats did not show any clinical signs of toxicity and morbidity in acute oral and dermal toxicity tests with the median lethal dose (LD) values of at least 5000 mg/kg and 2000 mg/kg body weight, respectively.

Safety assessment of a novel water-soluble extract of gum resin: acute toxicity, 90-day sub-chronic toxicity, Ames' bacterial reverse mutation, and micronucleus assays.

gum resin extracts have demonstrated potential benefits in alleviating joint pain and discomfort of osteoarthritis. The major objective of the present study was to assess the safety of a water-soluble gum resin extract (LI51202F1) in diverse models of acute oral, acute dermal, primary dermal irritation, eye irritation, and 90-day sub-chronic repeated dose toxicity studies, as well as Ames' bacterial reverse mutation assay and micronucleus assay. The acute oral and dermal toxicity studies in (SD) rats demonstrated that the median lethal dose (LD) of LI51202F1 is >2000 mg/kg body weight (BW).