Publications by authors named "T Gohda"
Aims/introduction: Fatty acid-binding protein (FABP) 4, which acts as an adipokine secreted by adipocytes, macrophages, and capillary endothelial cells, is expressed in injured glomerular cells. It has been reported that urinary (U-) FABP4 is associated with renal dysfunction and proteinuria in several glomerular kidney diseases. However, the clinical significance of U-FABP4 in diabetic kidney disease (DKD) remains undetermined.
View Article and Find Full Text PDFObjective: Although the effects of an unhealthy diet on the risks of diabetes and its renal complications are well understood, the effects of hygiene status have not been fully elucidated.
Research Methods And Procedures: We created four groups of mice according to the diet fed (standard [SD] or high-fat [HFD]) and their living environment (conventional [CV] or specific pathogen-free [SPF]), and characterized the extent of their kidney pathology, their gut microbiota, and their fecal short-chain fatty acid (SCFA) concentrations.
Results: The body masses and glycated hemoglobin levels of the HFD and CV groups were significantly higher than those of the SD and SPF groups, respectively.
Article Synopsis
- * Using mouse models, researchers found that renal injury activated the mineralocorticoid receptor (MR), which was linked to increased levels of HMGB1 and RAGE, and that blocking this pathway lessened kidney damage and inflammation.
- * Results indicate that HMGB1 is a key factor in the development of AKI and its progression to CKD by activating the Rac1/MR pathway, suggesting potential therapeutic targets for preventing kidney injury.
Background: Fatty acid-binding protein 4 (FABP4) is an adipokine that plays significant roles in the development of insulin resistance and atherosclerosis. High levels of soluble tumor necrosis factor receptors (TNFRs) including TNFR1 and TNFR2 are associated with renal dysfunction and increased mortality in patients with diabetes mellitus (DM). However, the association between circulating levels of FABP4 and TNFRs remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- Red yeast rice, used in making drinks and food in East Asia, has recently caused kidney problems in people taking certain supplements in Japan.
- A 58-year-old woman got sick after taking a supplement with red yeast rice, showing signs of kidney injury and high creatinine levels.
- After she stopped using the supplement and started treatment, her kidney health got better, highlighting that even health supplements can be harmful.