Assessment of fracture risk with FRAX and FRAXplus.

FRAX, a risk calculator that provides individualized 10-year probabilities of hip and major osteoporotic fracture, has been widely used for fracture risk assessment since its launch in 2008. It is now incorporated into very many guidelines worldwide to inform osteoporosis management. In this review, we explore the development of FRAX and how it enhances fracture risk prediction as compared to use of bone mineral density alone, as well as approaches to utilizing FRAX in determining intervention and assessment thresholds.

Impact of Clinical Surveillance on Outcomes of Locally Recurrent Nasopharyngeal Carcinoma.

Background: Local recurrence of nasopharyngeal carcinoma (NPC) occurs in 10%-20% of patients, with salvage potential in early recurrences. Yet, clear surveillance protocols are lacking. We compare survival outcomes and suitability for salvage in symptomatic and incidentally detected locally recurrent NPC.

IL-25 Enhances B Cell Responses in Type 2 Inflammation Through IL-17RB Receptor.

Background: Alarmin cytokine IL-25 promotes type 2 inflammatory responses in disorders such as asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) and known targets include ILC2 and Th2 cells. However, other cellular targets for IL-25 remain poorly defined.

Objective: To investigate induction and expression of IL-25 receptor (IL-17RB) by B cells and evaluate responsiveness of IL-17RB-expressing B cells to IL-25 in vitro.

Characterising the knowledge, attitudes and practices of Australian veterinarians regarding Q fever and the diagnosis and reporting of coxiellosis.

Q fever is a serious zoonotic disease that readily transmits from animals to humans. Infection in animals is known as coxiellosis. Veterinarians are in a key position to provide early detection of coxiellosis in animals that can aid the prevention or recognition of human cases.

Working-memory load decoding model inspired by brain cognition based on cross-frequency coupling.

Working memory, a fundamental cognitive function of the brain, necessitates the evaluation of cognitive load intensity due to limited cognitive resources. Optimizing cognitive load can enhance task performance efficiency by preventing resource waste and overload. Therefore, identifying working memory load is an essential area of research.