Publications by authors named "T Gernsheimer"
Article Synopsis
- Scientists studied people with low blood platelets who might bleed more easily, even when they got extra platelets.
- They found that 46% of the 330 participants experienced significant bleeding, with similar results for those taking medicine and those who didn’t.
- The research showed that having very low platelets and low red blood cells increased the risk of bleeding, suggesting that doctors might need to help raise red blood cell levels to prevent this.
Objectives: This study aims to demonstrate the potential of myoglobin saturation as an indicator of oxygen delivery adequacy to help determine the need for red cell transfusion.
Background: Modern blood management approaches have been established to optimise use of red blood cells for transfusions in patients with anaemia. However, most approaches make recommendations to transfuse based on haemoglobin or haematocrit levels and do not directly address adequacy of oxygen delivery.
Article Synopsis
- The study examines the limitations of the current WHO bleeding scale for evaluating bleeding in acute leukaemia patients, which doesn't adequately capture minor bleeds or the overall burden of bleeding.
- Through interviews with 19 healthcare providers (HCPs), the research identifies key features that should inform a new classification system for bleeding events in these patients.
- The findings categorize bleeding into three groups: clinically significant, potentially serious, and not significant, and propose the next steps include obtaining patient perspectives to improve the bleeding definition further.
Article Synopsis
- Up to one-third of patients with blood cancers who have received multiple transfusions develop immune-mediated issues that make platelet transfusions less effective, known as platelet transfusion refractoriness.
- This study analyzed 2012 platelet transfusions in 73 patients to examine how HLA antibodies and other patient factors influence the effectiveness of these transfusions, specifically looking at their impact on the corrected count increment (CCI) after 2 and 24 hours.
- Results showed that high levels of donor-specific antibodies, certain blood type mismatches, and other specific conditions negatively affected immediate posttransfusion platelet counts, suggesting that using a computerized algorithm for donor-recipient matching could improve outcomes in these patients.
Red blood cells (RBCs) have been hypothesized to support hemostasis by facilitating platelet margination and releasing platelet-activating factors such as adenosine 5'-diphosphate (ADP). Significant knowledge gaps remain regarding how RBCs influence platelet function, especially in (patho)physiologically relevant hemodynamic conditions. Here, we present results showing how RBCs affect platelet function and hemostasis in conditions of anemia, thrombocytopenia, and pancytopenia and how the biochemical and biophysical properties of RBCs regulate platelet function at the blood and vessel wall interface and in the fluid phase under flow conditions.
View Article and Find Full Text PDF