Publications by authors named "T Gernigon-Spychalowicz"
Article Synopsis
- The study focuses on the seasonal reproductive changes in the gerbil (Gerbillus gerbillus), particularly in male anatomy and behavior during breeding and resting seasons.
- During the breeding season, the testes are active with abundant sperm, and there is high expression of the G-protein-coupled oestrogen receptor 1 (GPER1) in several cell types, indicating intense spermatogenesis.
- In contrast, the resting season sees a significant reduction in testicular weight, halting of sperm production, and a changed expression pattern of GPER1, suggesting its key role in regulating these seasonal reproductive cycles.
Article Synopsis
- The study investigates the roles of androgens and estrogens in the epididymis of fat sand rats, focusing on the distribution of their receptors, particularly in the less-explored cauda region.
- Immunochemistry was used to analyze receptor presence during breeding and resting seasons, revealing distinct patterns of androgen (AR) and estrogen receptors (ESR1, ESR2) in principal and basal cells.
- Results indicate that sex steroid receptor activity varies seasonally and between different segments of the epididymis, suggesting a regulatory role for androgens and estrogens in reproductive functions.
The aim of this study was to visualize apoptosis throughout the reproductive cycle and after castration, castration then treatment with testosterone, and ligation of efferent ducts. The sand rat, Psammomysobesus, Cretzschmar 1828, is a diurnal rodent belonging to the family Gerbillidae. Its breeding cycle is seasonal with reproduction in autumn, winter and early spring and a short resting period from late spring to early summer.
View Article and Find Full Text PDFBackground: The efferent ducts are mainly involved in the reabsorption of the seminiferous tubular fluid. Testosterone and oestrogens regulate efferent ducts functions via their receptors.
Materials And Methods: This paper presents an experimental investigation on the location of the P450 aromatase, the 17-b oestradiol (E2), the androgen receptor (AR), the oestrogen receptor 1 (ESR1), the oestrogen receptor 2 (ESR2) and the G protein-coupled oestrogen receptor 1 (GPER1) in the efferent ducts using Psammomys obesus as an animal model to highlight the effect of the season on the histology and the distribution of these receptors.
Estrogen plays a crucial role in regulating epididymal function and development. Estrogen signaling is mediated via two main receptors essentially involved in the genomic regulating pathway: ERα and ERβ. Recent studies revealed the contribution of a novel estrogen receptor involved in the non-genomic pathway: GPER1.
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