Tunable on-chip optical traps for levitating particles based on single-layer metasurface.

Optically levitated multiple nanoparticles have emerged as a platform for studying complex fundamental physics such as non-equilibrium phenomena, quantum entanglement, and light-matter interaction, which could be applied for sensing weak forces and torques with high sensitivity and accuracy. An optical trapping landscape of increased complexity is needed to engineer the interaction between levitated particles beyond the single harmonic trap. However, existing platforms based on spatial light modulators for studying interactions between levitated particles suffered from low efficiency, instability at focal points, the complexity of optical systems, and the scalability for sensing applications.

Lymph node involvement in secondary breast angiosarcoma - a case presentation.

Angiosarcoma represents a group of rare tumors originating from vascular and lymphatic endothelial cells, characterized by marked aggressiveness, rapid growth and poor clinical outcome. The incidence of breast angiosarcoma accounts for approximately 0.05% of all malignant breast tumors and less than 1% of all sarcomas.

A Comprehensive Review of TRPS1 as a Diagnostic Immunohistochemical Marker for Primary Breast Carcinoma: Latest Insights and Diagnostic Pitfalls.

Background/objectives: Immunohistochemical expression of TRPS1 (trichorhinophalangeal syndrome type 1) protein is usually used by pathologists to confirm breast origin for triple-negative breast cancers (TNBC) or metastatic carcinomas of unknown primary. However, recent studies have reported TRPS1 expression in a variety of non-breast lesions. This review aims to provide a comprehensive evaluation of TRPS1 expression across various tumor types, highlighting both its diagnostic utility and potential pitfalls that may arise in clinical practice.

Somatic and germline mutations in endometrial cancer.

Endometrial cancer is a complex disease influenced by both somatic and germline mutations. While individual mutations in genes such as , and members of the DNA mismatch repair (MMR) system have been extensively studied, comprehensive analyses comparing somatic and germline mutations within the same cohort are limited. This study compares these mutations using whole exome sequencing (WES) data from tumor and blood samples in patients with endometrial cancer.

The Latest Data Concerning the Etiology and Pathogenesis of Irritable Bowel Syndrome.

Globally, irritable bowel syndrome (IBS) is present in approximately 10% of the population. While this condition does not pose a risk of complications, it has a substantial impact on the patient's quality of life. Moreover, this disease has a significant financial impact on healthcare systems.