Publications by authors named "T Ganguly"
The Innate Immune System Surveillance Biomarker p87 in African Americans and Caucasians with Small High-Grade Dysplastic Adenoma [SHiGDA] and Right-Sided Colon Mutations May Explain the Presence of Multiple Cancers Revealing an Important Minority of Patients with Mutations and Colorectal Neoplasia.
Gastrointest Disord (Basel)
June 2024
Unlabelled: Colorectal cancer (CRC) outcomes in terms of incidence and mortality are significantly worse in African Americans than other Americans. While differences in primary preventions for neoplasia (diet, obesity remediation, aspirin prophylaxis) are being elucidated, genetic mutations affecting premalignant lesions and immune response mechanisms may possibly also explain the increased incidence and mortality, particularly from right-sided disease.
Objective: Our team therefore examined colonic segments seeking to test the hypothesis that the immune response and somatic genetic profiles of the colonic anatomic segments may vary and thus account for variations in neoplasia risk among the various colonic segments revealing an antigenic relationship with precancerous lesions.
Article Synopsis
- Psoriasis is an inflammatory skin disease marked by red, scaly patches, influenced by genetic, epigenetic, and non-coding RNA factors, but lacks comprehensive studies integrating various genomic analyses.
- A multi-omics approach combining RNA-sequencing, small RNA-sequencing, and DNA methylation profiling revealed specific miRNAs and DNA methylation patterns that regulate key biological processes in psoriasis, particularly related to cell proliferation and immune responses.
- The study highlighted how the downregulated miRNA hsa-let-7c-5p can target genes that contribute to psoriasis, suggesting that manipulating miRNA levels could help manage the disease by reducing skin cell proliferation and inflammation.
Article Synopsis
- Temporal encephaloceles (TE) are a lesser-known cause of epilepsy that can be surgically treated, and this systematic review compiles data on their clinical characteristics and treatment outcomes.
- The analysis included 24 studies with a total of 423 patients, finding that TE patients typically have later seizure onset, different seizure patterns, and a greater incidence of idiopathic intracranial hypertension (IIH) compared to those without TE.
- Surgical interventions show promising outcomes, with a 75-85% success rate for different surgical techniques, indicating that better recognition and understanding of TE could improve epilepsy management.
Background: C-reactive protein (CRP) is a useful negative predictor of infectious complications following colorectal surgery. Whilst a CRP level below reported cut-offs on postoperative day (POD) 3 to 5 can be reassuring, it can be difficult to interpret an elevated CRP above these cut-offs. This study evaluated whether investigating an elevated CRP on POD 3-5 allows earlier detection of infectious complications.
View Article and Find Full Text PDFA cyclometalated iridium(III) complex bearing a self-immolative quinolinium moiety was developed as a ratiometric substrate for transfer hydrogenation studies. This photoluminescent probe allowed the rapid screening of a variety of Ir catalysts using a microplate reader, offering a convenient method to assess activity using a minimum amount of catalyst sample.
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