[The effect of nicotinamide on the activity of the glutathione- glutathione reductase system in subcellular fractions of regenerating rat liver].

Experiments on white rats have shown that growth rates of the glutathione reductase activity and reduced glutathione concentration in the cytoplasmic fraction of the generating liver tissue and especially in the mitochondrial one are more pronounced with an increase of the nicotinamide dose from 50 mg/kg to 150 mg/kg, than after administration of nicotinamide in a dose of 300 mg/kg. Higher doses of nicotinamide (500 mg/kg) produce less pronounced changes in these parameters.

[Substrate specificity of monoamine oxidase from the brain and liver of the human fetus during antenatal ontogenesis].

Dynamics of changes in the monoaminooxidase activity with respect to different substrates is characterized by a number of peculiarities and varies essentially in the process of ripening of the organs. Both in the brain and in the liver tyramine (a substrate of enzymes of types A and B), serotonin and norepinephrine (substrates of type A) and benzyl amine (substrate of type B) are subjected to oxidative deamination: tyramine--most intensely, serotonin and norepinephrine--less intensely and benzyl amine--least intensely.

[Comparative characteristics of the activity of enzyme systems for nitrogen metabolism in the liver of human fetuses during embryogenesis].

The activities of alanine aminotransferase (ES 2.6.1.

[Formation of some enzymic systems in the human fetal brain during development].

The data of studies in the monoaminoxidase, nuclease and transaminase activity in fractions of mitochondria and nuclei of the human fetus brain in the process of the fetus development evidence for the changes in the activity depending on the morphological and functional maturation of the organ during the antenatal ontogenesis. The monoaminoxidase activity increases by the time of birth. By the 40th week of development the activity of glutamic-aspartic transaminase increases as well.