TET1 participates in oxaliplatin-induced neuropathic pain by regulating microRNA-30b/Nav1.6.

Chemotherapy-induced neuropathic pain poses significant clinical challenges and severely impacts patient quality of life. Sodium ion channels are crucial in regulating neuronal excitability and pain. Our research indicates that the microRNA-30b (miR-30b) in rat dorsal root ganglia (DRG) contributes to chemotherapy-induced neuropathic pain by regulating the Nav1.

Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia.

Background: Intermediate phenotypes, such as characteristic neuroimaging patterns, offer unique insights into the genetic and stress-related underpinnings of neuropsychiatric disorders like depression. This study aimed to identify neuroimaging intermediate phenotypes associated with depression, bridging etiological factors to behavioral manifestations and connecting insights from animal models to diverse clinical populations.

Methods: We analyzed datasets from both rodents and humans.

Influence of the neck length of urease-powered flask-like colloidal motors on their kinematic behavior.

Enzyme-powered synthetic colloidal motors hold promising potential for medical applications because of their unique features such as self-propulsion, sub-micrometer size, fuel bioavailability, and structural and functional versatility. However, the key parameters influencing the propulsion efficiency of enzyme-powered colloidal motors still remain unclear. Here, we report the effect of the neck length of urease-powered pentosan flask-like colloidal motors on their kinematic behavior resembling the role of bacterial flagella.

The role of 15 mA and 77.5 Hz transcranial alternating current stimulation in blood pressure regulation: A post hoc analysis of a randomized controlled trial.

Background: Transcranial alternating current stimulation (tACS) at 77.5 Hz and 15 mA, targeting the forehead and mastoid areas, has proven efficacious in patients with major depressive disorder (MDD) by simultaneously stimulating multiple brain nuclei and regions, many of which are critical for blood pressure regulation. This post hoc analysis aimed to assess the potential blood pressure-lowering effects of 77.

Study of the N2 vibrational relaxation behaviors via the CO rovibrational thermometry.

This paper performed a comprehensive study of the thermal nonequilibrium effects of CO/Ar mixtures with various degrees of N2 additions and probed the N2 relaxation behaviors via the CO rovibrational thermometry. The rovibrational temperature time histories of shock-heated CO/N2/Ar mixtures were measured via a laser-absorption technique, and the corresponding vibrational relaxation data were summarized at 1890-3490 K. The measured results were compared with predictions from the Schwartz-Slawsky-Herzfeld (SSH) formula and the state-to-state (StS) approach (treating CO and N2 as pseudo-species).