[Path optimization of professional expertise in patients with hearing loss].

The article is devoted to finding ways to optimize the expertise of professional suitability of patients with hearing loss on the basis of practical experience. The paper discusses the need for the revision of the criteria for determining contraindications to continuing to work in noise and other harmful factors on the basis of current evidence-based medicine.

[Problems of diagnosis and prevention of occupational malignancies].

The authors presented statistics on quantity of registered occupational malignancies in Russian Federation and some foreign countries, analyzed causes of difficult diagnosis of occupational malignancies, suggested ways to improve the situation.

Purine release: a protective signaling mechanism of the mitochondrial permeability transition pore in ischemia.

Both mitochondrial permeability transition pore (PTP) opening and purine signaling are implicated in cardioprotection via ischemic preconditioning (IPC). The PTP opening is accomponied by release ofintramitochondrial solutes, and therefore we hypothesized that purine release from mitochondria during PTP opening may by required for IPC signaling. Herein we show that upon PTP opening, isolated mitochondria release adenosine, inosine and 3'-ribosyl uric acid monophosphate (3-RUAMP), and that perfused hearts subject to IPC release inosine and 3-RUAMP derivatives.

Radioprotective and antileukemic effects of growth factors in regenerating hematopoietic tissue.

We have examined the role of growth factors present in regenerating hematopoietic tissue in the prevention of some radiation-induced effects. These factors, extracted from calf spleen undergoing reparative regeneration, increased the 30-day survival of irradiated mice and partially decreased the incidence of leukemia in surviving mice. The growth factors modified the properties of leukemia cells in vitro, and could suppress residual leukemia cells in vivo.