[Cyclosporin A-sensitive mitochondrial pore as a target of cardioprotective action of hydrogen sulfide donor].

In experiments on a model of ischemia-reperfusion in Langendorff isolated rat hearts and isolated mitochondria we studied the role of hydrogen sulfide donor - sodium hydrosulfide (NaHS, 7.4 mg/kg) in modulating the sensitivity ofmitochondrial permeability transition pore opening. It was shown that NaHS increased the reserves of rat myocardium and had cardioprotective effects from ischemia-reperfusion.

[On results of operative conference of pulmonologists and occupational therapists in St. Petersburg and Leningrad region, concerning the topic "Justifying changes in "Occupational Diseases list" according to respiratory disease classification and global strategies of diagnosis, treatment and prevention of chronic obstructive pulmonary diseases (COLD) and bronchial asthma (GINA)"].

Results of operative conference of North-West Russia pulmonologists and occupational therapists were summarized and covered improvement of current list of occupational diseases. Resolution of the operative conference on the problem is presented.

[No-dependent modulation of the sensitivity of the mitochondrial permeability transition pore opening under ischemia-reperfusion of the isolated heart].

The role of nitric oxide (NO) in modulation of sensitivity ofmitochondnal permeability transition pore (MPTP) opening under exposure to calcium as inductor was studied in experiments on the isolated heart (on Langendorff) and isolated mitochondria. The MPTP opening was studied on the hearts under ischemia-reperfusion and of the mitochondrial calcium loading. We investigated the degree ofreperfusional injury of the heart functional state after preliminary administration of the classic inhibitor of MPTP opening: cyclosporin A, the nitroprussid sodium salt as NO donor, NO-synthase (NOS) inhibitors such as L-NMMA and aminoguanidin to perfusional solution, and also the influence of Ca+ in the range of concentrations (10(-8)-10(-4) M) on the mitochondrial swelling under its preincubation with L-NMMA (10(-4) M).

[Scientific activities of Occupational Medicine Department with St Petersburg Medical Academy for Postgraduate Education].

The article deals with materials devoted to 80th anniversary of scientific activities of Occupational Medicine Department with St Petersburg Medical Academy for Postgraduate Education. Theoretic, scientifical and practical data on achievements on various stages of longstanding history are presented. The authors prove the research carried by the Department to be important and promising for occupational hygiene and industrial medicine.

[Cardiodynamics and cardiac pump function in hyperthermia].

Breaking of myocardial pumping function was shown in experiments in anesthesized dogs under hyperthermia. The end-systolic, end-diastolic and stroke volume was decreased under those conditions. The effectiveness of Frank-Starling mechanism was reduced in severe hyperthermia.