Leptospiral Infection, Pathogenesis and Its Diagnosis-A Review.

Leptospirosis is a perplexing conundrum for many. In the existing literature, the pathophysiological mechanisms pertaining to leptospirosis is still not understood in full. Considered as a neglected tropical zoonotic disease, leptospirosis is culminating as a serious problem worldwide, seemingly existing as co-infections with various other unrelated diseases, including dengue and malaria.

Production, characterization and application of nanocarriers made of polysaccharides, proteins, bio-polyesters and other biopolymers: A review.

Chitosan, collagen, gelatin, polylactic acid and polyhydroxyalkanoates are notable examples of biopolymers, which are essentially bio-derived polymers produced by living cells. With the right techniques, these biological macromolecules can be exploited for nanotechnological advents, including for the fabrication of nanocarriers. In the world of nanotechnology, it is highly essential (and optimal) for nanocarriers to be biocompatible, biodegradable and non-toxic for safe in vivo applications, including for drug delivery, cancer immunotherapy, tissue engineering, gene delivery, photodynamic therapy and many more.

Chemical Composition of Ethyl Acetate Fraction and Its Biological Activity in Diabetic Human Dermal Fibroblasts.

Background: (MO), commonly known as the drumstick tree, is used in folklore medicine for the treatment of skin disease.

Objective: The objective of this study is to evaluate the ethyl acetate (EtOAc) fraction of MO leaves for antibacterial, antioxidant, and wound healing activities and conduct gas chromatography-mass spectrometry (GC-MS) analysis.

Materials And Methods: Antibacterial activity was evaluated against six Gram-positive bacteria and 10 Gram-negative bacteria by disc diffusion method.

Successful outcome of medical therapy in a case of acute massive pulmonary thromboembolism presenting with saddle thromboembolus.

Antemortem diagnosis of acute massive pulmonary thromboembolism (PTE) with a large thromboembolus at the bifurcation of the pulmonary trunk (saddle thromboembolus) is difficult, as most patients either die or are too ill for any diagnostic imaging. We report a case of massive PTE where constrast enhanced computed tomographic (CECT) scan of chest detected a saddle thromboembolus and showed its resolution with anticoagulant treatment. In our case, the presenting feature was unusual massive PTE as there was no haemodynamic instability or hypoxaemia.

Emphysematous pyelonephritis.

Emphysematous pyelonephritis is a rare life-threatening suppurative necrotising infection of the renal parenchyma and perirenal tissue producing abscess formation and intrarenal gas. It is almost always seen in diabetics, making it a concern of the physician. A high index of suspicion is required for diagnosis and a combined approach has significantly reduced the mortality.