[Anxiodepressive and neuromediatory disorders in hypertensive patients. Effects of cypramil therapy].

Aim: To investigate psychic status and characteristics of neuromediatory metabolism in hypertensive patients, efficacy of antihypertensive therapy with lisinopril and hydrochlorthiaside with adjuvant citalopram (cipramil) which is a selective inhibitor of serotonin reuptake.

Material And Methods: Fifty patients with hypertension stage II (37 females, 13 males, mean age 48 years, mean duration of the disease 10.6 years) have undergone psychometric examination, estimation of evoked potentials P-300, 24-h monitoring of blood pressure.

[The effect of steroid hormones and antimigraine preparations on serotonin transport in the thrombocytes of persons suffering from migraine and in healthy subjects].

The study tested the hypothesis that there are significant changes in the structure of serotonin transport system as a result of which steroid hormones in physiological concentrations are capable of interacting with this system of the patients. The influence of steroid hormones (estradiol, testosterone, hydrocortisone, corticosterone) as well as of migraine control preparations (nicergoline, methysergide, tolphenamic acid, cinnarizin, flunarizine) on the capture and release of (3H)-serotonin from the thrombocytes of patients with migraine and healthy subjects was compared. The systems mediating the capture and release of (3H)-serotonin from the thrombocytes of patients were found to be highly sensitive to certain steroid hormones and migraine control preparations.

[The effect of antimigraine preparations on serotonin transport in the brain synaptosomes of rats].

Methisergide and nicergoline act as competitive inhibitors whereas tolfenamic acid as a non-competitive inhibitor of 3H-serotonin accumulation which occurs with the involvement of the high-affinity system of serotonin uptake by the rat brain synaptosomes. Methisergide, nicergoline and tolfenamic acid at concentrations ranging close to Ki value were found to enhance the basal and K(+)-induced release of 3H-serotonin from the rat brain synaptosomes. The findings obtained indicate the ability of the drugs to disturb serotonin transport.