Publications by authors named "T G Prieto"
Single-cell sequencing has characterized cell state heterogeneity across diverse healthy and malignant tissues. However, the plasticity or heritability of these cell states remains largely unknown. To address this, we introduce PATH (phylogenetic analysis of trait heritability), a framework to quantify cell state heritability versus plasticity and infer cell state transition and proliferation dynamics from single-cell lineage tracing data.
View Article and Find Full Text PDFπ-Conjugated materials are highly attractive owing to their unique optical and electronic properties. Covalent organic frameworks (COFs) offer a great opportunity for precise arrangement of building units in a π-conjugated crystalline matrix and tuning of the properties through choice of functionalities or post-synthetic modification. With this review, we aim at summarizing both the most representative as well as emerging strategies for the synthesis of π-conjugated COFs.
View Article and Find Full Text PDFArticle Synopsis
- Somatic mutations can change chromatin accessibility, impacting how cells differentiate and causing abnormal growth, but studying this in human samples is complicated due to mixed cell types.* -
- The researchers created a technique called GoT-ChA, which connects specific genotypes to chromatin accessibility at a single-cell level, allowing for analysis of thousands of cells simultaneously.* -
- Their study on JAK2-mutant CD34 cells revealed that mutations lead to specific epigenetic changes that affect inflammation and differentiation, demonstrating the potential of GoT-ChA for exploring the relationship between somatic mutations and epigenetic changes in various cellular contexts.*