[Computerized tomography diagnosis of splenic and hepatic lesions in malignant non-Hodgkin's lymphomas].

Seventy eight patients with varying malignancy non-Hodgkin's lymphomas were examined. Signs of extranodal damage of the spleen and liver were studied. Spleno- and hepatomegaly were signs of the commonest diffuse visceral involvements.

[The clinico-morphological characteristics of malignant non-Hodgkin's lymphomas].

It was established that most patients with non-Hodgkin malignant lymphomas against the background of secondary immunodeficiency show an activation of the saprophytic bacterial and mycotic flora that results in the development of different infectious complications essentially, thus, influencing the course and prognosis of the disease. A dependence was established between the malignancy grade of non-Hodgkins lymphomas and frequency of development of non-infectious complications.

[Changes in functional activity of granulocytopoiesis in patients with rheumatoid arthritis].

Thirty-five RA patients with the disease history from 3 months to 15 years were examined. Seropositive RA was diagnosed in 19 patients, seronegative in 16 ones. A control group comprised 14 subjects aged 18-29.

[Effect of the blood sera of patients with different pathologies on normal and leukemic cells--the precursors of granulo- and monocytopoiesis].

A study was made of the effect of the blood sera of persons of the control group and patients with various diseases of the blood on normal precursor cells of granulo-monocytopoiesis (CFU-GM) and leukemic clonogenic cells. A stimulating human blood serum effect on proliferation was noted during cultivation of normal CFU-GM and leukemic clonogenic cells in the "agar drop-liquid medium" system. As a rule, the stimulating serum effect manifested itself in the presence of feeder cells or a high "spontaneous" colony formation.

[Clinical importance of the results of cloning hematopoietic cells from patients with leukemias and hematopoietic dysplasias].

The authors describe the results of the cloning of hemopoietic cells from 85 patients with different patterns of nonlymphoblastic leukemias in the agar drop--liquid medium system. It is shown that measurement of the colony-stimulating activity of hemopoietic cells and their growth pattern as well as morphological study of the cultures can be employed in practical hematology for making diagnosis and differential diagnosis, for evaluation of the treatment efficacy and prediction of the disease prognosis. The presence of blast colonies, an increase in the number of cell aggregations is regarded as an unfavourable prognostic criterion.