A bilayer small diameter vascular model for evaluation of drug induced vascular injury.

In pre-clinical safety studies, drug-induced vascular injury (DIVI) is defined as an adverse response to a drug characterized by degenerative and hyperplastic changes of endothelial cells and vascular smooth muscle cells. Inflammation may also be seen, along with extravasation of red blood cells into the smooth muscle layer (i.e.

[The combined application of enhanced external counterpulsation for the rehabilitation of the patients presenting with coronary heart disease].

We have studied the influence of enhanced external counterpulsation (EECP) applied in the combination with gaseous carbon dioxide baths and infrared laser therapy on the dynamics of clinical and functional abnormalities in the patients presenting with coronary heart disease (CHD) including those after surgical myocardial revascularization. The study was conducted on 40 patients of whom 20 suffered from chronic coronary heart disease and FC II-III angina of effort and the remaining 20 ones presented with coronary artery disease following myocardial revascularization (including 5 patients six months after coronary bypass grafting (CBG) and 15 ones three months after translumbar angioplasty (TLAP) in the combination with stenting of the coronary arteries). The study demonstrated that EECP in the combination with gaseous carbon dioxide baths and infrared laser therapy produced anti-ischemic and antianginal effects, stimulated myocardial contractility, contributed to economization of the cardiac activity, increased exercise tolerance, myocardial and coronary reserves.

[Statokinesitherapy in the patients presenting with coronary heart disease associated with arterial hypertension].

The introduction of statokinesitherapy with biological feedback into combined rehabilitative treatment of the patients presenting with coronary heart disease associated with arterial hypertension and clinical manifestations of dyscirculatory encephalopathy and/or vertebrobasilar insufficiency reduced the severity of clinical symptoms of cerebral syndromes. Specifically, it resulted in the decreased frequency of dizziness and shaky walk, improved coordination and sense of equilibrium, enhanced postural stability in the vertical position. The positive dynamics of clinical manifestations was confirmed by the results of stabilometry that suggested decreased deviation from the centre of pressure in the frontal and saggital directions and diminished total area of the statokinesiogram.

[Formation of focus of West Nile fever on the territory of Saratov Region].

Aim: Detection of circulation of West Nile virus (WNV) on the territory of Saratov Region and prerequisites for formation of natural focus of West Nile fever (WNF), determination of the role of WNV in infectious pathology on the territory of the region.

Materials And Methods: of organs of small mammals, birds, blood-sucking arthropods for the presence of WNV markers (antigens and/or RNA) were studied. Clinical material from patients with symptoms not excluding WNF was studied.

[The estimation of correlation dependences between the results of clinical examination and screening diagnostics of the risk factors of the development of cardiovascular diseases in the women of late reproductive age].

The results of clinical trials give evidence of the close correlation between the data obtained by clinical, biochemical, and instrumental methods and the data of screening studies designed to estimate the risk factors responsible for the development of cardiovascular diseases in the women of late reproductive age.