Publications by authors named "T G Kirilenko"
The occurrence of oligomannose-specific broadly neutralizing antibodies (bnAbs) has spurred efforts to develop immunogens that can elicit similar antibodies. Here, we report on the antigenicity and immunogenicity of a CRM-conjugate of a previously reported oligomannose mimetic. Oligomannose-specific bnAbs that are less dependent on interactions with the HIV envelope protein sequence showed strong binding to the glycoconjugates, with affinities approximating those reported for their cognate epitope.
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- Oligomannose-type glycans on HIV-1 gp120 are crucial for the effectiveness of broadly neutralizing antibodies (bnAbs), highlighting their significance in vaccine development.
- Attempts to create oligomannose-specific bnAbs through immunization with oligomannosidic glycoconjugates have had limited success, often attributed to B cell tolerance.
- Recent findings suggest that the trimming of oligomannosides by serum mannosidases in the body may further impede the development of antibodies capable of targeting the full-sized oligomannose, prompting the need for new immunization approaches or synthetic glycosides that resist this trimming.
The study data on the evaluation of future trends in research on social hygiene and public health organization are provided. It was an expert method that was used to study the opinion of leading scientists in social hygiene and of a large number of experts-managers of public health bodies and institutions. The computerised data permitted to determine the present and future priority problems in the field of social hygiene which could be used by research workers as a social goal for practical application.
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