[STATE OF NONALLERGIC HYPERSENSITIVITY UNDER THE EXPOSURE TO ADVERSE ENVIRONMENTAL FACTORS].

Now a number of allergopatologies is shown to be formed as non-allergic hypersensitivity. Research of this state is especially important when studying a question of formation of a condition of a chemical sensitization in response to the contact of a human body with chemical pollutants. For diagnostics of reactions of non-allergic hypersensitivity the test was developed for an assessment of activation of basophiles by specific allergens (the test of activation of basophiles by method of a flowing cytometry Flow Cast® (BD FACSCalibur)).

[Nonallergic hypersensitivity to environmental factors].

The prevalence and severity of manifestations of non-allergic hypersensitivity to chemical environmental factors pose the question about the need to study the mechanisms of its formation in population. It should be borne in mind that, in the absence of immunological mechanisms of formation of the mentioned state, the term "chemical sensitization" must be replaced by the term "non-allergic hypersensitivity." The investigation of this problem should permit to reduce the risk of formation of different types of hypersensitivity in population.

[Myofibrillar protein tropomyosin and allergic cross-reactivity].

Myofibrillar protein tropomyosin (TM) is a normal physiological protein participating in regulation of muscular contraction. It is widely prevalent among living organisms. This explains cross-reactivity of allergic patients to home dust, sea fish, cockroaches, etc.

[Risk factors of allergopathy].

This review contains a detailed description of factors which determine the allergic danger in a region, the sources of allergens entering the environment, and classification of allergens according to their origin and ecological significance. The authors draw attention to the existing criteria of allergopathic conditions, which may serve as an important diagnostic index when establishing sensitization and performing specific diagnostics of allergic diseases. The article covers a complex of laboratory diagnostic methods, directed towards timely detection of allergopathology and its prevention.

[Hygienic aspects of human sensitization under the influence of biological factors of the dwelling environment].

The paper deals with the risk of occurrence and development of allergic diseases under the influence of biological housing factors, such as molds, staphylococci, ticks, and insects. It shows that biological domestic allergens are of high importance in human sensitization. There is evidence that supports the allergic hazard of the above factors to children and adults.