Publications by authors named "T G England"
Article Synopsis
- The ProFATE trial investigated the impact of temporary blood flow arrest during endovascular thrombectomy on vessel recanalization in patients with acute ischemic stroke.
- Conducted across four UK centers, the study randomly assigned 134 adults to either a flow arrest or nonflow arrest group to assess the effectiveness of the procedure.
- Results showed a slight increase in vessel recanalization in the flow arrest group (74.4%) compared to the nonflow arrest group (70.8%), suggesting a potential benefit of temporary blood flow arrest during treatment.
Article Synopsis
- The study aims to address the growing issue of frailty in aging populations by analyzing its incidence, prevalence, and impact on healthcare demand and costs.
- Researchers conducted a retrospective observational study using routine health data from England and Wales to model frailty dynamics and inform service planning.
- Key findings will aid in developing guidelines and tools for healthcare commissioning, ultimately improving care for older people living with frailty.
Article Synopsis
- The study evaluated the safety and efficacy of glyceryl trinitrate (GTN) for patients experiencing transient ischaemic attack (TIA) during stroke trials, as part of the RIGHT-2 trial.
- Conducted as a multicenter, randomized, sham-controlled trial, the research involved administering GTN to patients with suspected ultra-acute stroke and assessing outcomes at 90 days using the modified Rankin Scale (mRS).
- Results showed that while GTN effectively lowered blood pressure, it did not improve functional outcomes or mortality rates compared to the sham treatment, indicating no benefit for TIA patients.
Background: The efficacy and safety of endovascular thrombectomy (EVT) beyond 6 hours from stroke onset for patients with large vessel occlusion (LVO) selected without CT perfusion(CTP) or MR imaging(MRI) is undetermined. We conducted a systematic review and meta-analysis of the current literature comparing outcomes for late presenting patients with LVO treated by best medical management (BMM) with those selected for EVT based only on non-contrast CT(NCCT)/CT angiography(CTA) (without CTP or MRI).
Methods: PRISMA guidelines were employed.
Cross-education describes the training of one limb that leads to performance enhancements in the contralateral untrained limb, driven by neural changes rather than muscle adaptation. In this systematic review and meta-analysis, we aimed to evaluate the efficacy of cross-education (vs. a control group) via resistance exercise training (RET) for improving muscle strength in the untrained lower limb of healthy males and females.
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