Publications by authors named "T Fydrich"
Background: The Personalized Advantage Index (PAI) shows promise as a method for identifying the most effective treatment for individual patients. Previous studies have demonstrated its utility in retrospective evaluations across various settings. In this study, we explored the effect of different methodological choices in predictive modelling underlying the PAI.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how physical exercise impacts working memory (WM) and brain activity in patients with Major Depression Disorder (MDD), focusing on the hippocampus.
- A total of 86 MDD patients participated in a 12-week program, divided into high intensity exercise (HEX), low intensity exercise (LEX), and a waiting list control group, with an n-back WM task used to measure cognitive performance before and after interventions.
- Results showed that both exercise groups improved their WM performance, particularly the HEX group, which also exhibited increased neural activation in the left hippocampus, though there were no significant structural changes in brain volume.
Article Synopsis
- The study investigates the impact of d-cycloserine (DCS) on anxiety levels during exposure therapy for patients with agoraphobia compared to a placebo group.
- A total of 73 patients underwent cognitive behavioral therapy with exposure sessions, with the DCS group showing reduced anxiety levels over time while the placebo group exhibited stable anxiety.
- Results indicate that DCS may have short-term benefits in managing anxiety during treatment, but further confirmatory research is necessary to validate these findings.
Article Synopsis
- Anxiety disorders impact brain connectivity, but how this varies among different types of anxiety disorders (like panic disorder and social anxiety disorder) isn't fully understood due to limited studies.
- Researchers examined the brain connectivity of 439 anxiety disorder patients and 105 healthy controls using resting-state fMRI, finding notable differences in connectivity patterns, especially in panic disorder and agoraphobia patients.
- The study revealed that panic disorder patients had increased connectivity in brain regions linked to emotion regulation, unlike those with social anxiety disorder or specific phobia, suggesting the potential for personalized treatment approaches based on these neurological differences.
The complexity of posttraumatic stress disorder (PTSD) symptoms related to childhood abuse (CA) present challenges for effective psychotherapeutic treatment. Consequently, there is great interest in the long-term effectiveness of psychological treatments for this population. This study aims to investigate the long-term outcomes of Dialectical Behaviour Therapy for PTSD (DBT-PTSD) and Cognitive Processing Therapy (CPT) 9 months after treatment termination.
View Article and Find Full Text PDF