Publications by authors named "T Furuse"
Purpose: A method was developed to measure strabismic angles >50 by stacking commercially available Fresnel and block prisms in the same direction ("piggyback prisms").
Methods: With a laser pointer (wavelength of 532 nm) as the light source, the deviation of the laser spot produced by the stacked prisms was measured on a tangent screen placed 100 cm away from the prisms. To the obtained data with combinations of Fresnel prisms (5-40) and block prisms (10-50), a cubic surface function was fitted by polynomial regression.
Article Synopsis
- - Increased lactate levels from glycolysis are being studied as potential markers for metabolic changes in neurons, linked to a drop in brain pH, which has been associated with various neuropsychiatric disorders like schizophrenia and autism.
- - Research shows that these pH and lactate changes are common across different animal models, including those for depression, epilepsy, and Alzheimer's disease, though findings vary, particularly within the autism spectrum.
- - A large-scale analysis indicated that higher lactate levels correlate with worse working memory performance, suggesting that altered brain chemistry might reflect underlying conditions across multiple disorders.
Article Synopsis
- DExH-box helicases, involved in unwinding RNA and DNA, include genes like DHX30, which is linked to neurodevelopmental disorders; DHX9's variants have not been widely associated with such disorders until now.
- A new report highlights a patient with a de novo missense variant in DHX9 linked to short stature, intellectual disability, and a heart condition, with the variant located in the ATP-binding site.
- Experiments with Drosophila and gene-editing in mice demonstrate that loss-of-function variants in DHX9 can lead to neurodevelopmental issues, supporting its role in these conditions.
The type 2 Ca-dependent activator protein for secretion (CAPS2/CADPS2) regulates dense-core vesicle trafficking and exocytosis and is involved in the regulated release of catecholamines, peptidergic hormones, and neuromodulators. CAPS2 is expressed in the pancreatic exocrine acinar cells that produce and secrete digestive enzymes. However, the functional role of CAPS2 in vesicular trafficking and/or exocytosis of non-regulatory proteins in the exocrine pancreas remains to be determined.
View Article and Find Full Text PDFProtocadherin 9 (Pcdh9) is a member of the cadherin superfamily and is uniquely expressed in the vestibular and limbic systems; however, its physiological role remains unclear. Here, we studied the expression of Pcdh9 in the limbic system and phenotypes of Pcdh9-knock-out mice (Pcdh9 KO mice). Pcdh9 mRNA was expressed in the fear extinction neurons that express protein phosphatase 1 regulatory subunit 1 B (Ppp1r1b) in the posterior part of the basolateral amygdala (pBLA), as well as in the Cornu Ammonis (CA) and Dentate Gyrus (DG) neurons of the hippocampus.
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