Publications by authors named "T Furlanetto"
The ectoenzyme CD73, encoded by the NT5E gene, has emerged as a potential prognostic and therapeutic marker for papillary thyroid carcinoma (PTC), which has increased in incidence in recent decades. Here, from The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) database, we extracted and combined clinical features, levels of NT5E mRNA, and DNA methylation of PTC samples and performed multivariate and random forest analyses to evaluate the prognostic relevance and the potential of discriminating between adjacent non-malignant and thyroid tumor samples. As a result, we revealed that lower levels of methylation at the cg23172664 site were independently associated with BRAF-like phenotype (p = 0.
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- Papillary thyroid cancer (PTC) is more common in women, with studies suggesting estrogen's role in increasing this incidence, particularly through 17β-estradiol (E2) affecting thyroid cell behavior.
- The study focuses on G protein estrogen receptor 1 (GPER1) gene and protein expression in PTC versus non-malignant thyroid tissues, revealing lower GPER1 levels in PTC and its association with clinical features like metastasis, female gender, and BRAF mutations.
- Results indicate that GPER1 may influence PTC tumorigenesis and suggests it could be a potential target for therapy, calling for more research into its functions in both normal and cancerous thyroid tissues.
Objective: To evaluate seasonal variation of 25(OH)vitamin D [25(OH)D3] levels, and factors associated with it, in healthy adult men, who exercised outdoors for 50 min., at least twice a week, from 10AM to 4PM, in a Brazilian semitropical region.
Methods: Blood samples were collected at the end of each season for 25(OH)D3, measured by liquid chromatography with tandem mass spectrometry.
Objective: This prospective study aimed to assess the concurrent validity and diagnostic accuracy of a mathematical procedure for measurement of the spinal inclination angle, analogous to the Cobb angle, by means of photogrammetry.
Methods: Sixty-one subjects (aged 7 to 18 years), male and female, underwent radiographic (Cobb angle) and photogrammetric (DIPA [Digital Image-based Postural Assessment] angle) evaluations. The measurement of spinal inclination angle obtained through photogrammetry followed the Digital Image-Based Postural Assessment software protocol.
Objective: Advances in mobile technology have led to the development of smartphones, whose applications present numerous utilities, such as the analysis of human movement based on inertial sensors. The purpose of this review was to investigate validity and reliability of smartphones in assessing the kinematics of the human spine.
Methods: A systematic search was performed on MEDLINE, Embase, Scopus, and LILACS databases, as well as manual searches.