Publications by authors named "T Fukusato"
Article Synopsis
- - The rising need for efficient data analysis in biomedical research is driving the use of workflow systems, which help researchers streamline and execute data analysis steps, especially in high-throughput DNA sequencing.
- - The diversity of workflow systems in the research community has led to fragmented efforts, making it challenging for researchers to learn and utilize all available systems when accessing shared workflows.
- - To address this issue, Sapporo was developed as a unified application that simplifies workflow execution across various systems, featuring an API and a client interface that supports multiple workflow languages, thereby enhancing resource utilization in data analysis.
Immunostaining with p57KIP2 is a widely used diagnostic technique to differentiate complete hydatidiform moles (CHMs) from partial hydatidiform moles (PHM) and non-molar hydropic abortion. However, distinguishing between PHMs and non-molar hydropic abortions using histopathology alone is often challenging. This study aimed to evaluate the technical validity and additional benefits of using fluorescence in situ hybridization (FISH) in combination with p57KIP2 immunostaining to diagnose molar and non-molar conceptuses.
View Article and Find Full Text PDFNonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat accumulation in the livers of patients without a history of alcohol abuse. It is classified as either simple steatosis (nonalcoholic fatty liver) or nonalcoholic steatohepatitis (NASH), which can progress to liver cirrhosis and hepatocellular carcinoma (HCC). Recently, it was suggested that the terms "metabolic dysfunction-associated steatotic liver disease (MASLD)" and "metabolic dysfunction-associated steatohepatitis (MASH)" should replace the terms "nonalcoholic fatty liver disease (NAFLD)" and "nonalcoholic steatohepatitis (NASH)", respectively, with small changes in the definitions.
View Article and Find Full Text PDFBackground: Reproducibility of data analysis workflow is a key issue in the field of bioinformatics. Recent computing technologies, such as virtualization, have made it possible to reproduce workflow execution with ease. However, the reproducibility of results is not well discussed; that is, there is no standard way to verify whether the biological interpretation of reproduced results is the same.
View Article and Find Full Text PDFArticle Synopsis
- * Although advancements in noninvasive diagnosis methods exist, liver biopsy remains the most reliable way to diagnose NAFLD/NASH, but it depends on the subjective interpretation of pathologists, leading to inconsistencies in results.
- * Artificial intelligence (AI) is emerging as a promising tool to enhance diagnostic accuracy and objectivity in pathology, and several studies—including some by our research group—show its potential in the diagnosis of NAFLD/NASH.