Early eosinophilia after hematopoietic stem cell transplantation is associated with chronic graft-versus-host disease.

Background: This study aimed to evaluate whether an early elevation of absolute eosinophil count after allogeneic hematopoietic stem cell transplantation (allo-HSCT) was associated with the development of chronic graft-versus-host disease (cGVHD) in children and adolescents.

Methods: A total of 165 consecutive patients who received allo-HSCT were included in the study. Patients who had previously received allo-HSCT, relapsed or died before Day 100, and did not achieve engraftment, were excluded.

The effect of anticoagulation therapy on the surgical outcomes of minimally invasive major gastrointestinal surgery.

Background: The surgical outcomes of minimally invasive surgery (MIS) for gastrointestinal (GI) cancers in patients receiving anticoagulation therapy (ACT) are unknown. We investigated the effect of ACT on the surgical outcomes of minimally invasive major GI surgery, with a particular focus on postoperative bleeding and thromboembolic complications.

Methods: A total of consecutive 1290 patients undergoing elective minimally invasive (laparoscopic and robotic) major GI surgery (esophagogastric and colorectal resection for malignancy) between 2014 and 2023 were enrolled.

Cord Blood Transplantation Using Myeloablative Conditioning for Pediatric Advanced Myelodysplastic Syndrome in AMeD Syndrome With a Novel ADH5 Variant.

Aplastic anemia, mental retardation, and dwarfism syndrome (AMeDS) is a rare inherited bone marrow failure syndrome. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only possible treatment option for hematological complications in AMeDS; however, there are no reports addressing allo-HSCT for AMeDS. A 6-year-old female diagnosed with AMeDS accompanying myelodysplastic syndrome with increased blast was successfully treated with cord blood transplantation followed by myeloablative conditioning (MAC).

Phyllodes Tumor of the Breast Enlarged by Hemorrhagic Infarction: A Case Report.

Breast phyllodes tumors are rare mesenchymal tumors, often accompanied by internal cysts, hemorrhages, infarctions, and necrosis. The tumor exhibits rapid growth, especially when infarct necrosis occurs within the tumor. In the current report, we showed a woman in her 50s who noticed a rapidly growing breast mass and received an excisional biopsy diagnosis of a phyllodes tumor with hemorrhagic infarction.