Publications by authors named "T Friedlander"
Introduction: Consultation audio recordings improve patient decision-making but are underutilized. Patient-administered recording apps on mobile devices may increase access, but implementation has not been evaluated.
Methods: We conducted a single-arm study delivering education, coaching, and reminders for patients to record their appointment using a mobile recording app.
Rising winter temperatures jeopardize the fruit yield of trees that require a prolonged and sufficiently cold winter to flower. Predicting the exact risk to different crop varieties is the first step in mitigating the harmful effects of climate change. This work focused on olive (Olea europaea) - a traditional crop in the Mediterranean basin whose flowering depends on the sufficiency of cold periods and the lack of warm ones during the preceding winter.
View Article and Find Full Text PDFHER2, encoded by the ERBB2 gene, is an important druggable driver of human cancer gaining increasing importance as a therapeutic target in urothelial carcinoma (UC). The genomic underpinnings of HER2 overexpression in ERBB2 nonamplified UC are poorly defined. To address this knowledge gap, we investigated 172 UC tumors from patients treated at the University of California San Francisco, using immunohistochemistry and next-generation sequencing.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how biological networks, specifically in plant self-incompatibility systems, evolve to prevent self-fertilization through complex molecular interactions between female and male proteins.
- A new theoretical framework is introduced that allows for more interactions between proteins and recognizes the importance of diversity in mating partners, which previous models overlooked.
- The findings reveal that this promiscuity in molecular recognition promotes the formation of different "classes" within the population and indicates potential applications of the framework in other biological systems.
Article Synopsis
- * Recent updates to the NCCN Guidelines for Bladder Cancer reflect changes from the fifth edition of the WHO Classification of Tumours, ensuring alignment with new standards.
- * The guidelines also introduce new treatment options for NMIBC that doesn't respond to bacillus Calmette-Guérin (BCG) therapy and provide updated recommendations for systemic therapy targeting advanced or metastatic bladder cancer.