Publications by authors named "T Francuz"
The role of adipose mesenchymal stem cells (Ad-MSCs) in metabolic syndrome remains unclear. We aimed to assess the expression of selected microRNAs in Ad-MSCs of non-diabetic adults in relation to Ad-MSC secretion of protein regulators and basic metabolic parameters. Ten obese, eight overweight, and five normal weight subjects were enrolled: 19 females and 4 males; aged 43.
View Article and Find Full Text PDFOpinions on the effects of osteoprotegerin (OPG) have evolved over the years from a protein protecting the vasculature from calcification to a cardiovascular risk factor contributing to inflammation within the vascular wall. Nowadays, the link between OPG and angiotensin II (Ang II) appears to be particularly important. In this study, the endothelial function was investigated in OPG-knockout mice (B6.
View Article and Find Full Text PDFDiabetes is one of the leading chronic conditions worldwide, and breast cancer is the most prevalent cancer in women worldwide. The linkage between diabetes and its ability to increase the risk of breast cancer should always be analyzed in patients. This review focuses on the impact of antihyperglycemic therapy in breast cancer patients.
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- Vascular endothelial growth factor (VEGF) is important in both the development and healing of tendinopathy, with genetic variations affecting how patients respond to treatment.
- A study analyzed 107 patients with tennis elbow over two years, focusing on how five specific gene polymorphisms influenced the success of platelet-rich plasma (PRP) therapy.
- Results showed that certain genetic variants (GG for rs2010963 and CC for rs3024998) were linked to a better response to PRP treatment, suggesting that genetic testing could help personalize therapy for tendinopathy patients.
Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes which are members of the zinc endopeptidase family. They have the ability to degrade extracellular matrix elements, allowing for the release of binding molecules and cell migration. Although metalloproteinases regulate numerous physiological processes within the cornea, overexpression of metalloproteinase genes and an imbalance between the levels of metalloproteinases and their inhibitors can contribute to the inhibition of repair processes, the development of inflammation and excessive cellular proliferation.
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