Publications by authors named "T Francisco"
Article Synopsis
- Memories are formed in the brain during learning and become stable through a process called reactivation after the learning phase.
- A strong negative experience in mice leads to the reactivation not just of that recent memory, but also of a related neutral memory formed two days earlier, linking these memories in a way that influences future fear responses.
- The study suggests that this co-reactivation happens more during wakefulness and helps the brain integrate and relate different memories over time.
Stress can have profound consequences on mental health. While much is known about the neural circuits supporting associative memories of stressful events, our understanding of the circuits underlying the non-associative impacts of stress, such as heightened stress sensitivity and anxiety-related behavior, is limited. Here, we demonstrate that the ventral hippocampus (vHC) and basolateral amygdala (BLA) support distinct non-associative behavioral changes following stress.
View Article and Find Full Text PDFThe Kröhnke Pyridine Synthesis has been discovered about six decades ago (1961), by Fritz Kröhnke and Wilfried Zecher at the University of Giessen. The original method involved the reaction of α-pyridinium methyl ketone salts with α,β-unsaturated carbonyl compounds in the presence of a nitrogen source, frequently ammonium acetate. Since its discovery, the Kröhnke methodology has been demonstrated to be suitable for the preparation of mono-, di-, tri- and tetra-pyridines, with important applications in several research fields.
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- - Alzheimer's disease (AD) is a growing health challenge, especially in developed countries, due to longer life expectancies, but currently lacks a standard method for early diagnosis and effective treatment options.
- - The monoclonal antibody lecanemab has opened up new possibilities for drug development and has sparked interest in small molecules, which could be simpler, cheaper, and easier for patients to use at home.
- - Small-molecule near-infrared fluorescent theranostics are attracting attention for their dual role in diagnosing and treating AD, potentially replacing expensive methods and paving the way for personalized medicine in patients.
PEX5, the peroxisomal protein shuttling receptor, binds newly synthesized proteins in the cytosol and transports them to the organelle. During its stay at the peroxisomal protein translocon, PEX5 is monoubiquitinated at its cysteine 11 residue, a mandatory modification for its subsequent ATP-dependent extraction back into the cytosol. The reason why a cysteine and not a lysine residue is the ubiquitin acceptor is unknown.
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