Publications by authors named "T Fraisse"
Objectives: Orphan medicinal products (OMPs) authorized by the European Union (EU) benefit from market exclusivity, fee waivers, and national incentives. Maintaining orphan status during a marketing authorization application requires meeting eligibility criteria, especially demonstrating significant benefit (SB), which is challenging. This study identifies key features linked to successful orphan status maintenance for biological OMPs approved in the EU between 2018 and 2023.
View Article and Find Full Text PDFBackground: In geriatrics, explicit criteria for potentially inappropriate prescriptions (PIPs) are useful for optimizing drug use.
Objective: To produce an expert consensus on explicit definitions of antibiotic-PIPs for hospitalized older patients.
Methods: We conducted a Delphi survey involving French experts on antibiotic stewardship in hospital settings.
Objectives: This study aimed to estimate the prevalence of ANCA-associated vasculitis (AAV). That is, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), in Southern France in 2018, and evaluate differences among Europeans and non-Europeans.
Methods: This population-based, cross-sectional study used four sources (hospitals, community-based physicians, laboratories, National Health Insurance) to identify adults ≥15 years diagnosed with GPA, MPA or EGPA, living in Hérault and Gard in 2018.
Article Synopsis
- The study investigated the use of transoesophageal echocardiography (TEE) in elderly patients (≥75 years) with infective endocarditis (IE) and its effects on their treatment and mortality rates.
- It found that older patients who did not undergo TEE had worse overall health, fewer surgeries indicated, and higher mortality rates, despite having similar IE characteristics compared to those who had TEE.
- The research highlights the importance of TEE in accurately diagnosing cardiac lesions and improving management, suggesting that underdiagnosis in older patients could lead to poorer outcomes.
The assessment of mood disorders and addiction linked to the practice of chemsex is of interest given the psychoactive substances used. The aim of this study was to assess risky sexual and addictive behavior to chemsex and related anxiety/depression symptoms in individuals receiving HIV pre-exposure prophylaxis (PrEP). In this cross-sectional study, all adults presenting for PrEP renewal at French sexual health centers were enrolled from January 2018 to March 2019.
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