Publications by authors named "T Florian"
Background: Intrathoracic migration of a ventriculoperitoneal shunt (VPS) is a phenomenally rare complication, with the supradiaphragmatic intercostal variant even more so. Whereas it can prove debilitating or even fatal via massive hydrothorax, the causative mechanism and proper management of this occurrence are undefined.
Case Presentation: A 17-month-old girl who had undergone VPS insertion at one month of age was brought to our department for somnolence and dyspnea, which had a sudden onset.
Article Synopsis
- Inflammatory cytokines like TNF-α, IL-23, IL-17A, and IL-17F may play a crucial role in the development and severity of psoriasis, prompting researchers to study their correlation with disease progression.
- The study involved 23 adult psoriasis patients undergoing biological therapy (ixekizumab, secukinumab, guselkumab, or adalimumab), measuring disease severity (PASI and DLQI scores) and cytokine levels before and after 3 months of treatment.
- Results showed that biological therapies improved PASI and DLQI scores as well as reduced cytokine levels, with IL-23 emerging as a potential biomarker for assessing treatment response, despite not consistently correlating with
Inflammation and oxidative stress are interrelated processes, during which many pathological processes lead to the reactive oxygen species (ROS) and the cytokines release. The aim of this experimental study was to analyse the effects of chlorogenic acid, in oral daily administration, against the oxidative stress and oedema development in experimental carrageenan-induced rat paw inflammation. The oxidative stress parameters were investigated after a paw inflammation was produced in rats that previoulsy received, for 14 days, either chlorogenic acid (100 mg/day or 150 mg/day) or indomethacin (1 mg/kg/day).
View Article and Find Full Text PDFEffects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemia-reperfusion.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
July 2006
Article Synopsis
- The study evaluates the cardioprotective effects of osajin and pomiferin, two compounds isolated from the fruit of Maclura pomifera, using rat hearts as a model for testing antioxidant therapy against ischemia-reperfusion injury.
- The research involved four groups of Wistar rats, where two groups received the isoflavones, while the other two served as a placebo and control group, with various biochemical and functional heart parameters measured after treatment.
- Results indicated that both osajin and pomiferin improved heart function and decreased oxidative stress, suggesting their potential as protective agents against heart damage caused by ischemia-reperfusion events.
The study was undertaken to evaluate the cardioprotective potential of the flavonoids osajin and pomiferin against ischemia-reperfusion induced injury in rat hearts as a model of antioxidant-based composite therapy. Studies were performed with isolated, modified Langendorff-perfused rat hearts and ischemia of the heart was initiated by stopping the coronary flow for 30 min followed by 60 min of reperfusion (14 ml x min(-1)). Wistar rats were divided into four groups.
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