Publications by authors named "T Fiers"
Sexual dimorphism influences cardiovascular outcomes in type 1 diabetes (T1D), with women facing a higher relative risk of macrovascular events compared to men, especially after menopause. This study hypothesizes that abnormalities in intermediate metabolism may be associated with cardiac autonomic neuropathy (CAN) in T1D. We aim to assess low molecular weight metabolites (LMWM) as markers of CAN in T1D, considering the effects of sexual dimorphism and age.
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- Evidence-based guidelines suggest that liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a more accurate method than automated immunoassays for diagnosing biochemical hyperandrogenism in women with polycystic ovary syndrome (PCOS).
- A study involving 359 premenopausal women with symptoms of hyperandrogenism showed that the agreement between results from immunoassays and LC-MS/MS was poor, and LC-MS/MS altered PCOS diagnoses in about 15.8% of the cases.
- The findings indicate that routine immunoassays are unreliable for PCOS phenotyping, and there are inconsistencies in using serum anti-müllerian hormone (AMH) alongside ultrasound for diagnosis, raising
Study Question: Is resting energy expenditure (REE) altered in women with polycystic ovary syndrome (PCOS)?
Summary Answer: Women with PCOS have a reduction in REE, when corrected for fat-free mass, independent of PCOS clinical phenotypes and BMI categories.
What Is Known Already: Obesity is an important issue in women with PCOS, in terms of frequency and pathophysiological implications. It has been hypothesized that obesity may be favoured by alterations in REE, but the studies have been limited and conflicting.
Article Synopsis
- Genetic variation in sex hormone-binding globulin (SHBG) can influence testosterone (T) levels, potentially leading to inaccurate diagnoses if not considered.
- A study of 999 healthy men (ages 25 to 45) explored how specific genetic variations (SNPs) in SHBG affect the measured and estimated levels of free testosterone.
- Results showed that while certain SNPs led to significant changes in total testosterone and SHBG levels, the impact on calculated or measured free testosterone was minimal, with a notable trend observed only in rs6259 homozygotes.
Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway.This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone.
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