Publications by authors named "T Fazil Aki"
Article Synopsis
- Thallium (Tl) is a toxic heavy metal, and recent studies focus on its effects in the kidneys, revealing notable molecular mechanisms related to its toxicity.
- In an experiment, rats were given Tl2SO4, and analysis showed that ribosomal proteins were significantly upregulated, indicating increased ribosome production and protein translation in response to Tl exposure.
- However, mitochondrial biogenesis declined, with a disruption in the signaling pathway of Myc, suggesting a failure to coordinate ribosomal and mitochondrial responses during Tl toxicity in the kidneys.
Background: This study investigated the impact of total knee arthroplasty (TKA) on the alignment of the ankle joint, focusing on changes in coronal alignment of both ankles.
Methods: This retrospective study, conducted at our hospital, included 64 patients older than 70 years who underwent TKA for varus knee osteoarthritis (OA). Using full-length standing radiographs of both lower extremities taken preoperatively and 6 months postoperatively, we assessed ankle OA grading based on the Takakura-Tanaka classification and measured mechanical hip-knee-ankle (mHKA) and the tibiotalar angle (TTA) on both the surgical and contralateral side.
This study investigates the impact of age and knee osteoarthritis (OA) on the coronal plane alignment of the lower extremity in Japanese males and females, utilizing the Coronal Plane Alignment of the Knee (CPAK) classification system. A cross-sectional analysis was conducted with 150 male and 150 female patients. Participants were divided into three groups according to age and OA progression.
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- Thallium (Tl) is a highly toxic heavy metal linked to accidental poisoning and can cause severe health issues including kidney failure.
- In a study on rats, intraperitoneal administration of Tl led to significant kidney dysfunction, characterized by high calcium deposits and mitochondrial issues in a specific kidney region called the medullary thick ascending limb (mTAL).
- The research found that inhibiting a specific kidney transporter helped reduce Tl accumulation and its damaging effects, which could lead to new treatment strategies for Tl poisoning and improve diagnostic methods for related kidney damage.
Article Synopsis
- - Chronic subdural hematoma (CSDH) often recurs, and this study examines the effects of middle meningeal artery embolization (MMAE) on treated cases and the timing of this treatment.
- - Out of 72 patients with initially recurring CSDH, those who had a shorter time between first and second recurrences were more likely to experience repeat issues, with 37.5% having a second recurrence.
- - Early MMAE, within 52.4 days after initial surgery, was linked to a higher risk of recurrence and a shorter interval before recurrence compared to patients who were treated later.