Evolution of Extraintestinal Manifestations in Patients With Ulcerative Colitis Post-Restorative Proctocolectomy and Ileal Pouch-Anal Anastomosis: A Single-Center Retrospective Study.

Background And Aims: Extraintestinal manifestations (EIMs) are common in patients with ulcerative colitis (UC). However, the prevalence and associated factors of EIMs in UC patients post-restorative proctocolectomy with ileal pouch-anal anastomosis (RPC + IPAA) are not well established.

Methods: We extracted clinical, demographic, and laboratory data of all UC patients who underwent IPAA surgery and followed up in our comprehensive pouch clinic between 2003 and 2021.

Lung Ultrasound Training for Respiratory Therapists.

Bedside ultrasound is widely utilized for critically ill patients, yet there is no standardized approach for teaching lung ultrasound to medical staff, particularly respiratory therapists (RTs), in the United States. Thus, we aimed to evaluate the efficacy of a lung ultrasound training program designed for RTs. With approval from the ethics committee, we recruited RTs with over 3 months of experience at Rush University Medical Center to participate in our lung ultrasound training program.

Proprotein Convertase Subtilisin/Kexin Type 9 Induction in Hypercholesterinemic Patients With Primary and Metastatic Liver Tumors.

Background/aim: Serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are positively associated with serum cholesterol levels, which contribute to the growth of cancers. PCSK9 levels are low in patients with liver cirrhosis, with a high incidence of hepatocellular carcinoma (HCC). PCSK9 expression is increased in colorectal cancer (CRC), but serum levels in these patients have not been analyzed.

Construction of an Atlas of transcription factor binding during mouse development identifies popular regulatory regions.

Gene regulators physically associate to the genome, in a combinatorial fashion, to drive tissue-specific gene expression. Uncovering the genome-wide activity of all gene regulators across tissues is therefore needed to understand gene regulation during development. Here, we take a first step towards this goal.

Complications After Maternal Traumatic Brain Injury During Pregnancy: A Systematic Review.

Importance: General trauma is the leading cause of nonobstetric maternal morbidity and mortality, affecting approximately 8% of all pregnancies. Pregnant women with traumatic brain injury (TBI) face high morbidity and mortality rates, requiring complex management due to physiological changes, teratogenic risks of treatments, and the need for fetal monitoring.

Objectives: To assess the consequences of TBI during pregnancy on maternal and fetal outcomes and to evaluate management strategies to inform clinical decision-making.