Sentinel lymph node detection in thyroid carcinoma using [Ga]Ga-tilmanocept PET/CT: a proof-of-concept study.

Purpose: Sentinel lymph node (SLN) biopsy is rarely used for thyroid carcinoma staging. This is due to challenges associated with conventional Tc-99m-labeled tracers, often producing a large hotspot at the injection site, potentially hiding nearby SLNs (shine-through effect). The aim of this study was to demonstrate the feasibility and effectiveness of SLN visualization using the new PET tracer [Ga]Ga-tilmanocept.

Patient Preparation with Esomeprazole Is Comparable to Ranitidine in Meckel Diverticulum Scintigraphy.

To localize ectopic gastric mucosa in patients with unexplained gastrointestinal bleeding and diagnose a Meckel diverticulum, Tc-pertechnetate imaging is the standard procedure. H2 inhibitor pretreatment enhances the sensitivity of the scan by reducing washout of Tc activity from the intestinal lumen. We aim to provide evidence of the effectiveness of the proton pump inhibitor esomeprazole as an ideal substitute for ranitidine.

Dosing Therapeutic Radiopharmaceuticals in Obese Patients.

The prevalence of obesity has increased dramatically in the Western population. Obesity is known to influence not only the proportion of adipose tissue but also physiological processes that could alter drug pharmacokinetics. Yet, there are no specific dosing recommendations for radiopharmaceuticals in this patient population.

Antenatal maternal antidepressants drugs treatment affects S100B levels in maternal-fetal biological fluids in a dose dependent manner.

Background: The increased use of antidepressant treatment during pregnancy occurred without firm evidence on safety/efficacy. The present study investigated the correlation among S100B and paroxetine blood levels with the occurrence of short-term post-natal neurological abnormalities.

Methods: We conducted a cross-sectional study in 50 pregnant women using paroxetine because of depression and in 150 controls.

First Experience With 177Lu-PSMA-617 Therapy for Advanced Prostate Cancer in the Netherlands.

Purpose: The present study summarizes the first experience with Lu-PSMA-617 (Lu-PSMA) treatment in metastatic castration-resistant prostate cancer (PCa) in our institution.

Methods: This was an analysis of the first 30 consecutive patients who underwent Lu-PSMA therapy. Biochemical response was defined as prostate-specific antigen decrease of 50% or greater.