Publications by authors named "T F Stoop"
Purpose: To assess the association between neoadjuvant therapy and overall survival (OS) in patients with left-sided resectable pancreatic cancer (RPC) compared to upfront surgery.
Background: Left-sided pancreatic cancer is associated with worse OS compared to right-sided pancreatic cancer. Although neoadjuvant therapy is currently seen as not effective in patients with RPC, current randomized trials included mostly patients with right-sided RPC.
Objective: To investigate the incidence and risk factors of portomesenteric venous thrombosis (PVT) after pancreatic cancer surgery with portomesenteric venous resection (PVR).
Summary Background Data: Pancreatic cancer surgery with PVR can be complicated by PVT, but the long-term associations, risk factors, and consequences of PVT have not been clearly elucidated.
Methods: This study included pancreatic cancer patients undergoing any type of pancreatic resection with PVR at the University of Colorado Hospital between January 2012 and June 2023.
Article Synopsis
- The study investigates whether total pancreatectomy (TP) provides better oncological outcomes than partial pancreatectomy (PP) for patients with high-risk IPMN-associated cancer, focusing on local recurrence and secondary progression.
- It compares data from 359 patients, showing that while TP offers improved local disease-free survival (local-DFS), there is no significant difference in overall survival (OS) between TP and PP.
- The findings suggest that TP could be more beneficial for younger patients who are likely to benefit from reduced recurrence risk, while elderly patients may not see the same advantage in OS.
Objective: To measure the rate of LTS in resected PDAC and determine the association between predictors of OS and LTS.
Summary Background Data: Long-term survival (>5 y, LTS) remains rare in pancreatic ductal adenocarcinoma (PDAC). Multiple predictors of overall survival (OS) are known but their association with LTS remains unclear.