[Interaction of sensory neurons and satellite cells during stimulation of the nerve regeneration].

Using the model of pharmacological stimulation of rat sciatic nerve regeneration, the effect of pyrimidine derivative ximedon on survival of different populations of LIV-LV dorsal root ganglion neurons, their expression of antiapoptotic Bcl-2 protein and number of neurons surrounded by vimentin-positive satellite cell, was studied. 90 days after nerve cutting, ximedon was found to reduce posttraumatic death of neurons having both medium-sized and large perikarya by 35.5% and 42.

Effect of xymedon on cell survival in the system sensory neuron Schwann cell.

Pyrimidine derivative xymedon inhibits neuronal death in L4-L5 spinal ganglia 30 days after ligation of rat sciatic nerve. After treatment with xymedon the number of neurons on the operated side decreased by 22.1% compared to that on the contralateral side, while in the control group this parameter decreased by 28.