Savoring Uncertainty.

The first quantification of neural discharge from the carotid body of cats in response to hypoxia, hypercapnic acidosis, and their combination discovered a strong potentiating effect of hypoxia and hypercapnic acidosis combined as compared to either alone. This paper was the start of a research journey that eventually examined the regulation of blood and cerebrospinal pH by peripheral and central chemoreceptors in the setting of systemic acid-base alterations. This research focus was the result of the author's personal fascination with mountains and human adaptation to high altitude-an interest that led to his own ascent of Mount Everest in 1963.

Risk factors for relapse in health care professionals with substance use disorders.

Context: Substance use disorders among physicians are important and persistent problems. Considerable debate exists over whether use of major opioids, especially among anesthesiologists, is associated with a higher relapse rate compared with alcohol and nonopioids. Moreover, the risk factors for relapse with current treatment and monitoring strategies are unknown.

Unchanged cerebral blood flow and oxidative metabolism after acclimatization to high altitude.

The authors investigated the effect of acclimatization to high altitude on cerebral blood flow and oxidative metabolism at rest and during exercise. Nine healthy, native sea-level residents were studied 3 weeks after arrival at Chacaltaya, Bolivia (5,260 m) and after reacclimatization to sea level. Global cerebral blood flow at rest and during exercise on a bicycle ergometer was measured by the Kety-Schmidt technique.