Publications by authors named "T F Deutsch"
Glucagon-like peptide-1 receptor agonists (GLP1RAs) effectively reduce body weight and improve metabolic outcomes, yet established peptide-based therapies require injections and complex manufacturing. Small-molecule GLP1RAs promise oral bioavailability and scalable manufacturing, but their selective binding to human versus rodent receptors has limited mechanistic studies. The neural circuits through which these emerging therapeutics modulate feeding behavior remain undefined, particularly in comparison to established peptide-based GLP1RAs.
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- The study focuses on predicting the risk of severe toxicity from cancer treatments using machine learning algorithms, addressing a significant concern for patients.
- Clinical data from 590 breast cancer patients was analyzed to develop and validate two algorithms, with enhancements in predictive accuracy achieved by incorporating treatment information alongside patient characteristics.
- Results indicate that machine learning can effectively forecast treatment-related toxicity, offering a potential strategy to enhance treatment safety and management for cancer patients.
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- * This study aimed to evaluate the HER2 status of CTCs in mBC patients over three months of treatment, especially the implications for HER2-low cases, which are becoming increasingly relevant with new therapies involving antibody-drug conjugates (ADCs).
- * Results showed a discrepancy in HER2 status between CTCs and tumor tissues in 30.2% of patients, highlighting the challenges in diagnostic accuracy and the need for improved monitoring approaches in mBC treatment.
Article Synopsis
- The BETTER-CARE study is investigating a personalized follow-up care system for breast cancer patients in Germany, focusing on individual needs and risks of long-term therapy side effects.
- It is a cluster-randomized controlled trial involving 30 centers aiming to recruit 1,140 patients, with the primary goal of improving health-related quality of life.
- The pilot phase showed that the approach is feasible, and if successful, it could become a part of routine care in Germany.
Article Synopsis
- Primary care goes beyond treating illness to include preventive care and chronic disease management, with Practice-Based Research Networks (PBRNs) like RaPHaeL in Germany providing essential support for clinical research.
- A survey of general practitioners involved in RaPHaeL assessed their demographic characteristics, infrastructure, and research readiness, revealing a 97.1% response rate and a mix of participants in terms of age and practice size.
- The study identified a significant variability in the readiness of GP practices for conducting clinical research, indicating a need for targeted training to improve their capabilities and enhance healthcare delivery.