Publications by authors named "T F Buss"
Article Synopsis
- Modern medicine aims to enhance treatment effectiveness while minimizing side effects, with nanoparticles (NPs) offering promising potential for targeted drug delivery and imaging.
- However, the small size of NPs often leads to quick removal from the bloodstream and limited effectiveness due to challenges in crossing important cell barriers.
- This research demonstrates a method to exploit endothelial caveolae in the lungs to improve NP delivery, achieving higher lung concentrations than in the bloodstream, which could enhance both diagnostics and therapies in future medical applications.
The long-sought-after "magic bullet" in systemic therapy remains unrealized for disease targets existing inside most tissues, theoretically because vascular endothelium impedes passive tissue entry and full target engagement. We engineered the first "dual precision" bispecific antibody with one arm pair to precisely bind to lung endothelium and drive active delivery and the other to precisely block TGF-β effector function inside lung tissue. Targeting caveolae for transendothelial pumping proved essential for delivering most of the injected intravenous dose precisely into lungs within one hour and for enhancing therapeutic potency by >1000-fold in a rat pneumonitis model.
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- Biological invasion poses a significant risk to global biodiversity and ecosystem services, prompting an analysis of native versus non-native invasive tree species in Southern Brazil's subtropical mixed forest.
- The study utilized Principal Component Analysis to assess traits like wood density, leaf area, and specific leaf area, aiming to understand how invasive species fit into ecological niches.
- Although both native and non-native species share functional gradients, the success of invasions is influenced by specific traits and cannot be generalized across all species.
Evaluation of a portable device for assessment of motility in stallion semen.
Reprod Domest Anim
March 2019
In horse breeding, quality assessment of semen before insemination is often requested. Non-laboratory-based techniques for objective analysis of sperm motility are thus of interest. The aim of this study was evaluating a portable device for semen analysis (Ongo sperm test) and its comparison with computer-assisted semen analysis (CASA).
View Article and Find Full Text PDFPrimary hyperparathyroidism is a condition with hypercalcemia and elevated parathyroid hormone (PTH). Typically, treating patients with such disease does not pose a problem for doctors, unless the patient is pregnant. Firstly, pregnancy may mask signs of hypercalcemia.
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