Publications by authors named "T F Brito"
Amphotericin B (AmB) is a commonly utilized antifungal agent, which is also recommended for the treatment of certain neglected tropical diseases, including leishmaniasis. However, its clinical application is constrained because of its poor oral bioavailability and adverse effects, prompting the investigation of alternative drug delivery systems. Polymeric nanoparticles (PNPs) have gained attention as a potential drug delivery vehicle, providing advantages such as sustained release and enhanced bioavailability, and could have potential as AmB carriers.
View Article and Find Full Text PDFBackground: Owing to their extensive utilization as pesticides, heterocycles assume a fundamental role in the management of vector-borne diseases. Despite the presence of numerous heterocyclic compounds in commercial insecticides and larvicides, resistance to pesticides still demands novel strategies to current pest control methods. Considering these facts, this review aims to survey the synthesis and SAR of heterocyclic molecules with larvicidal activity against Aedes aegypti Linn.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the role of Piwi proteins and piRNAs in protecting the genome of
- Rhodnius prolixus
- , a hemipteran insect known to transmit Chagas disease, from DNA damage caused by horizontally transferred transposable elements (HTTs) acquired from its diet.
- - By using SmallRNA-Seq and RNA-Seq techniques, researchers quantified piRNA features and gene expression levels, revealing that piRNA production peaks during embryogenesis, correlating with reduced expression of HTTs and resident transposable elements.
- - The findings highlight that while resident transposable element piRNAs engage in a typical ping-pong amplification mechanism, the response to HTTs is different, suggesting unique biogenesis and functional pathways for pi
Objective: To identify factors associated with poor sleep quality in elderly dependent individuals in social vulnerability.
Method: Cross-sectional study with 59 elderly dependent individuals assisted by Family Health Units in São Carlos/SP. The following tools were used: Katz Index, Lawton and Brody Scale, Pittsburgh Sleep Quality Index, Addenbrooke's Cognitive Examination Revised, Fried's Frailty Phenotype, Geriatric Depression Scale (15 items), Perceived Stress Scale, Family APGAR, Social Support Scale from the Medical Outcomes Study, and World Health Organization Quality of Life, abbreviated and "old" versions.
Article Synopsis
- Five new lignanamides and ten known amides were extracted from the roots' chloroform extract, with new compounds identified through NMR and mass spectrometry.
- The absolute configuration of one compound was determined using ECD experiments and quantum mechanical calculations.
- The anti-inflammatory effects of these compounds were tested on macrophages, showing that all reduced nitric oxide levels, while one compound did not significantly affect IL-10 levels, indicating potential anti-inflammatory properties.