Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis.

The limited availability of therapeutic options for patients with triple-negative breast cancer (TNBC) contributes to the high rate of metastatic recurrence and poor prognosis. Ferroptosis is a type of cell death caused by iron-dependent lipid peroxidation and counteracted by the antioxidant activity of the selenoprotein GPX4. Here, we show that TNBC cells secrete an anti-ferroptotic factor in the extracellular environment when cultured at high cell densities but are primed to ferroptosis when forming colonies at low density.

Effects of disliked music on psychophysiology.

While previous research has shown the positive effects of music listening in response to one's favorite music, the negative effects of one's most disliked music have not gained much attention. In the current study, participants listened to three self-selected disliked musical pieces which evoked highly unpleasant feelings. As a contrast, three musical pieces were individually selected for each participant based on neutral liking ratings they provided to other participants' disliked music.

Physical and CFD model used in the analysis of particles dispersion.

Air pollution, representing one of the major environmental crises affecting us all, is responsible for half a million deaths each year in Europe. This research shows a numerical model based on Computational Fluid Dynamics (CFD) and a methodology for its validation allowing to know the evolution of particles in open urban environments. In this case, the model represents an area of Gijón (Asturias), specifically chosen as it serves to highlight a location at which the daily limit values of PM set by the regulations are most frequently exceeded.