Perinatal health in Spain during and after the Great Recession: Educational selection into fertility as a protective factor in high unemployment contexts.

Higher maternal resources have long been associated with superior birth outcomes. This study analyzes the potentially protective role of maternal educational selection into fertility in adverse macroeconomic contexts. We focus on the case of Spain, a country reaching record-high unemployment levels during the Great Recession starting in 2008.

Specific methylation of the CpG-rich domains in the promoter of the human tissue transglutaminase gene.

The activity of tissue transglutaminase is present in many cells and tissues but almost absent in leucocytes and lymphocytes. The present work describes the distribution of 5-methylcytosine along the bisulphite-converted promoter of the human tissue transglutaminase gene as being in an essentially repressed state. In this promoter, the chain-specific sequencing revealed the location of three CpG-rich domains whose methylation responds to an 'all or nothing' signal.

A protein kinase inhibitor from A431 subline overexpressing TGF alpha possesses antimicrobial activity.

During the last decade the key role of antimicrobial peptides in innate immunity has been argued. They were found in plants and in different phylogenic groups of animals (insects, amphibia, and even in mammals). We report the production of a human peptide antibiotic that was previously characterized as an EGF receptor tyrosine kinase inhibitor in epidermoid carcinoma A431/1522 cell subline overexpressing TGF alpha.