Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy.

Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer's disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-associated neuroinflammation is the NF-κB and NLRP3 signaling axis. However, current treatments targeting NF-κB or NLRP3 may have adverse/systemic effects, and most have not been clinically translatable.

Metal- ligand-centered reactivity of a cobalt-phenylenediamide complex with electrophiles.

A new series of [Co-CF] complexes supported by a bidentate redox-active ligand is presented. The cationic [Co-CF] complex was first obtained by reacting [CpCo(opda)] (Cp = cyclopentadienyl, opda = -phenylenediamide) with an electrophilic trifluoromethyl source, for which the redox-active phenylenediamide ligand serves as a 2e reservoir to generate [CpCp(bqdi)(CF)] (bqdi = benzoquinonediimine). Electrochemical studies of [Co-CF] revealed two reversible 1e reductions.

Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy.

Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer's disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-associated neuroinflammation is the NF-κB and NLRP3 signaling axis. However, current treatments targeting NF-κB or NLRP3 may have adverse/systemic effects, and most have not been clinically translatable.

Cage Match: Comparing the Anion Binding Ability of Isostructural Versus Isofunctional Pairs of Metal-Organic Nanocages.

Affinities of six anions (mesylate, acetate, trifluoroacetate, p-toluenecarboxylate, p-toluenesulfonate, and perfluorooctanoate) for three related Pt -linked porphyrin nanocages were measured to probe the influence of different noncovalent recognition motifs (e. g., hydrogen bonding, electrostatics, π bonding) on anion binding.

Metal-Ligand Proton Tautomerism, Electron Transfer, and C(sp)-H Activation by a 4-Pyridinyl-Pincer Iridium Hydride Complex.

The -N-pyridyl-based PCP pincer proligand 3,5-bis(di--butylphosphinomethyl)-2,6-dimethylpyridine (pN-PCP-H) was synthesized and metalated to give the iridium complex (pN-PCP)IrHCl (). In marked contrast with its phenyl-based congeners, e.g.